And what is maximum node(physical/virtual machine) we can keep in one DC ?
You can have as many nodes in your cluster as you can afford since it is virtually limitless. The number of nodes is only limited by the number of hash values the partitioner can generate.
Using the default (and recommended) Murmur3Partitioner, it can generate hash values from a possible range of -2^63 to 2^63 - 1. That range of values is so large which is why I said it's virtually limitless.
In practical terms, I've worked on clusters with several hundred nodes (300-700) to over a thousand nodes. Cheers!
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